Description

ARA-290 (Also known as Cibinetide)

ARA-290 is a synthetic 11-amino acid peptide derived from the helix B domain of erythropoietin (EPO). Unlike full-length EPO, ARA-290 selectively activates the innate repair receptor (IRR) without stimulating erythropoiesis (red blood cell production). It is primarily researched for its potential in neuroprotection, tissue repair, and anti-inflammatory activity.

Research Properties:

Anti-Inflammatory Effects: ARA-290 has been studied for its ability to reduce pro-inflammatory cytokines such as IL-6, IL-12, and TNF-α, making it of interest in chronic inflammation and autoimmune research models.
Nerve Repair & Neuroprotection: Shows significant potential in promoting nerve fiber regeneration and functional recovery in models of neuropathic pain and nerve damage.
Tissue Protection & Wound Healing: Research indicates it may accelerate wound healing and improve tissue survival, particularly in diabetic and ischemic models.
Immune Modulation: Being investigated for its role in modulating immune responses in various inflammatory conditions.

Key Areas of Research Interest:

Neuropathic pain and diabetic neuropathy
Sarcoidosis-associated small fiber neuropathy
Tissue repair and regeneration
Inflammatory and autoimmune conditions
Cardiovascular and retinal protection

Note: ARA-290 has been evaluated in multiple Phase II and Phase III clinical trials for various indications, though it remains a research compound.

For Research Use Only. Not for human consumption. ARA-290 is intended strictly for laboratory research and in-vitro experimentation.

CORE FEATURES

ARA-290: A Research Peptide Overview

ARA-290, a synthetic peptide derived from erythropoietin (EPO), has gained attention in research for its potential neuroprotective, anti-inflammatory, and tissue-protective effects. Designed to selectively activate the innate repair receptor (IRR) without stimulating erythropoiesis, ARA-290 is studied for its role in promoting cellular repair and reducing inflammation, making it a promising candidate for research in neuroprotection and regenerative medicine.

Key Research Areas

Neuroprotection: ARA-290 is widely studied for its ability to protect neurons from damage caused by inflammation, oxidative stress, or ischemia in experimental models, relevant for neurodegenerative disease research.
Inflammation Modulation: Researchers are investigating ARA-290’s potential to reduce inflammatory responses by targeting the IRR, supporting studies on inflammatory and autoimmune conditions.
Tissue Repair and Regeneration: Preliminary studies have explored ARA-290’s role in promoting tissue repair, particularly in neural and vascular tissues, relevant for wound healing and regenerative research.

Why Choose ARA-290 for Research?

ARA-290’s high specificity for the innate repair receptor and its potent effects on neuroprotection and inflammation modulation make it a valuable tool for studying mechanisms of cellular repair and inflammatory pathways. Its stability and targeted design enable researchers to explore therapeutic applications in neurodegenerative disorders, inflammation, and tissue regeneration.

Important Note

ARA-290 is offered exclusively for laboratory research purposes. It is not approved for human or animal use, nor is it intended to diagnose, treat, cure, or prevent any disease or condition.