Description

Vasoactive Intestinal Peptide (VIP)

Vasoactive Intestinal Peptide (VIP) is a 28-amino acid neuropeptide naturally produced in the hypothalamus and various other tissues, including immune cells, endocrine cells, and the gastrointestinal tract. It functions as a potent neuromodulator and hormone with wide-ranging effects on circadian rhythms, immune regulation, inflammation, cardiovascular function, and respiratory health. VIP is actively researched for its therapeutic potential in chronic inflammatory conditions, respiratory disorders, neurodegenerative diseases, and mold-related illnesses such as Chronic Inflammatory Response Syndrome (CIRS).

Key Benefits

Circadian Rhythm & Sleep Regulation: Helps maintain sleep-wake cycles, improves sleep quality, and may assist with insomnia, jet lag, and delayed sleep phase syndrome.
Respiratory Health: Acts as a bronchodilator, improves mucociliary clearance, and reduces pulmonary hypertension. Studied for asthma, COPD, and other respiratory conditions.
Anti-Inflammatory Effects: Reduces pro-inflammatory cytokines (TNF-α, IL-6) and increases anti-inflammatory mediators (IL-10). Research interest in rheumatoid arthritis, IBD, MS, and septic shock.
Cardiovascular Support: Promotes vasodilation, improves coronary blood flow, and lowers peripheral resistance.
Neuroprotection: Supports neuronal survival, reduces neuroinflammation, and shows potential in Parkinson’s and Alzheimer’s disease.
Gut Health: Regulates gut motility, secretion, and microbiota balance.
Erectile Function: Used in combination therapies (e.g., Invicorp) to improve blood flow.
CIRS & Mold Toxicity: Key component in the Shoemaker Protocol for treating Chronic Inflammatory Response Syndrome.

Administration Options

Subcutaneous (SQ) Injection: Most common method, typically administered in the evening to support circadian rhythm.
Nasal Spray: Preferred for direct central nervous system and respiratory delivery, often used for neurological and respiratory conditions.

Note: VIP has a short half-life and requires careful dosing and monitoring.

Potential Side Effects

Generally Well-Tolerated under medical supervision.
Common (Mild): Injection site reactions, nasal irritation (with spray), dizziness, flushing, or low blood pressure.
Rare/Serious: Potential for pancreatitis (lipase levels should be monitored monthly during treatment).
VIPoma Consideration: Excessive VIP production from rare endocrine tumors can cause severe diarrhea and electrolyte imbalances, highlighting the need for proper monitoring.

Note: VIP is not FDA-approved for most uses and is primarily used for research purposes.

CORE FEATURES

VIP Peptide: A Research Peptide Overview

Vasoactive Intestinal Peptide (VIP), a naturally occurring 28-amino-acid peptide, has garnered significant interest in research for its role in modulating inflammation, neuroprotection, and cellular signaling. VIP is studied for its ability to interact with specific receptors (VPAC1, VPAC2, and PAC1), influencing various physiological processes. Its broad biological activity positions VIP as a promising candidate for research in neurobiology, immunology, and regenerative medicine.

Key Research Areas

Inflammation Modulation: VIP is widely studied for its potent anti-inflammatory effects, particularly its ability to regulate immune responses and reduce pro-inflammatory cytokines in experimental models.
Neuroprotection and Neuroregeneration: Researchers are investigating VIP’s potential to protect neurons and promote neural repair, making it relevant for studies on neurodegenerative conditions and brain injury.
Cellular Signaling and Homeostasis: VIP is explored for its role in modulating cellular signaling pathways, including cAMP activation, which may support tissue repair and metabolic regulation.

Why Choose VIP for Research?

VIP’s high specificity for its receptors and its multifaceted effects on inflammation, neuroprotection, and cellular signaling make it a valuable tool for studying complex physiological processes. Its stability and targeted action enable researchers to explore therapeutic pathways in immunology, neurology, and regenerative medicine.

Important Note

VIP is offered exclusively for laboratory research purposes. It is not approved for human or animal use, nor is it intended to diagnose, treat, cure, or prevent any disease or condition.